Why the Paleo Diet will not work for Autoimmune Disease Patients

Why the Paleo Diet will not work for Autoimmune Disease Patients


– Hi I’m Doctor Datis Kharrazian, and I wanna talk to you about different dietary protocols and regiments and specifically the autoimmune paleo diet and when that person has autoimmunity. Now technically, when
people have autoimmunity one of the first things they notice is that inflammatory proteins,
especially things like gluten, especially things like
dairy or even neoantigens or new proteins, that have
been modified, like GMO soy or GMO corn and even things like albumen. These proteins are all common inflammatory proteins for
people with autoimmunity, they really they notice
when they avoid these things that they get much better. And then we also know that
certain grains can cross react with gluten, so over
time one of the things that’s been developed
is what’s being called the autoimmune paleo diet. And we would, before the
autoimmune paleo diet became popular and it was named
the autoimmune paleo diet, you know, we would see patients come in and they’d suffered from autoimmunity and we would see that they
would basically be eating meats and vegetables and that they
couldn’t tolerate things like nightshades and they
couldn’t handle seeds and they couldn’t handle
grains and so forth. And that was the only thing
they could function on. And over time we really realized that these food combinations
can be an issue for, their food proteins
are a significant issue if you have autoimmune diseases and lots of research
has been done on this, including research that
I’ve published myself, on this topic. But what we know is that
autoimmune paleo diet is probably the most
important diet for people who have autoimmune disease, that they need to be
gluten free, dairy free and go off grains. And many patients also have reactions to what are called lectins or nightshades, these are very inflammatory proteins, and nuts and seeds of different
vegetables and so forth. And when they get exposed to them this can be very inflammatory. But there’s some problems with
the autoimmune paleo diet. First of all, when patients go
on the autoimmune paleo diet many of them also have
complete food restrictions, so they narrow down their list, this impacts your diversity
and they get much worse because one of the things that we know about autoimmune disease
is you have to have something called oral tolerance. And oral tolerance is your
immune systems ability, specifically your gut
immune systems ability, to not react against
dietary food proteins. And this is done with orchestration and balance of dendritic cells
in the gut that sample food and regulatory T cells that
then dictate the immune response and the integrity of the
intestinal tight junctions and these all work in sync together. But one of the things
that has to happen is that bacteria in the gut produce things called postbiotics and different polysaccharides and they impact all these immune cells and that really helps us
determine whether we react or not react to food proteins and having a diverse microbiome
is essential for that. So one of the big mistakes
we see with people with the autoimmune paleo
diet is they just kinda go “well I can’t eat anything, so I’m just gonna eat these foods,” and then they eat these foods only and they limit their diet,
they lose their diversity and they actually end
up having more reactions to just eating. And this is a serious problem. The other key thing is that many foods in the autoimmune paleo
diet can actually cause molecular mimicry or cross react to neurological target proteins. So we’ve studied some publications where spinach has aquaporin and people have MS or neuromyelitis optica
can react to spinach because the protein structure of spinach, even though it’s permitted
in the autoimmune paleo diet, can cause significant molecular mimicry with the autoimmune target protein. So one of the things we’re
gonna do is we’re gonna go over all these topics and really discuss the
concept of food proteins and how they trigger autoimmunity in the Kharrazian institute
autoimmune course. And we’ll talk about
all the different ways to evaluate patients and then what kind of dietary
regiments to implement and also how important it is
to not just limit yourself, or your patients to the
autoimmune paleo diet but really look at factors
like cross reactivity and immune tolerance. Hope to see you at the
Kharrazian institute autoimmune course and thank
you for your attention.