Exercise-induced autophagy and its role in preventing diabetes | Guido Kroemer

Exercise-induced autophagy and its role in preventing diabetes | Guido Kroemer


But the other thing that induces autophagy,
you’re mentioning the stress response and oxidative oxygen, and it sort of reminded
me of exercise and how exercise also induces autophagy. I’ve seen some studies where in humans, they’ve
looked at muscle, skeletal muscle, and how aerobic exercise and eccentric and concentric
exercise all can activate autophagy in skeletal muscle. Do you know if it activates autophagy in multiple
tissues? Exercise? [Dr. Kroemer]: That’s something that we have
not studied. So, it is known that endurance training is
particularly efficient in mice to induce autophagy and that it mediates anti-obesity and anti-diabetic
effects that are depending, in a way, on autophagy induction, because genetic modifications of
the process that leads to autophagy induction, it’s inhibition, specifically by exercise,
can prevent these anti-diabetic effects. [Rhonda]: Really? [Dr. Kroemer]: Yeah. [Rhonda]: Oh, I didn’t know that the role
of the exercise in preventing diabetes was shown to be dependent on autophagy to some
degree. That’s very interesting. So, do you think that has to do with the liver,
and the like pancreas, somewhere… I mean, is it known? [Dr. Kroemer]: To know this in detail, it
would be necessary to inhibit autophagy specifically in different tissues and, to my knowledge,
this has not been done yet. [Rhonda]: Okay. So do you think fasting while you’re like
exercising in a fasted state… Now, that’s another thing that’s…do you
think that would be important? Or do we… I mean, I’ve seen some studies in mice where
they claim it is, but mice have a very high metabolism. And so, there’s a synergy there. But when you look in humans, it’s not so important. Like, the exercise can still induce autophagy
in skeletal muscle in humans even without being in a fasted state, but the question
is like will you synergize more and… [Dr. Kroemer]: You can speculate, but we don’t
know. [Rhonda]: I’m giving you a lot of ideas here.